Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Assessment of the Abdomen III: Palpation01:23

Assessment of the Abdomen III: Palpation

Palpation is a crucial tactile examination method for assessing abdominal organs and detecting conditions like tenderness, distention, masses, or fluid. It involves both light and deep palpation techniques, each serving specific diagnostic purposes. Light palpation helps identify tenderness and other surface-level indicators, while deep palpation locates and assess abdominal masses and organ boundaries. A skilled professional can gather valuable insights through palpation, including evaluating...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Of giraffes' necks and the inheritance of chromatin states.

Nature genetics·2017
Same author

Corrigendum to "Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster" [Mech. Dev. 128 (2012) 536-547].

Mechanisms of development·2017
Same author

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.

Nucleic acids research·2016
Same author

The Necessity of Chromatin: A View in Perspective.

Cold Spring Harbor perspectives in biology·2016
Same author

Histone Marks Direct Chromosome Segregation.

Cell·2015
Same author

Genome-wide activities of Polycomb complexes control pervasive transcription.

Genome research·2015

Related Experiment Video

Updated: Jun 25, 2026

Renal Corpuscle
01:20

Renal Corpuscle

6.9K

Polycomb repression under the skin.

Vincenzo Pirrotta1

  • 1Department of Molecular Biology & Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. pirrotta@dls.rutgers.edu

Cell
|March 24, 2009
PubMed
Summary
This summary is machine-generated.

Polycomb group proteins regulate gene expression during stem cell differentiation. Their repression controls the timing of epidermal lineage precursor cell differentiation.

More Related Videos

Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

Related Experiment Videos

Last Updated: Jun 25, 2026

Renal Corpuscle
01:20

Renal Corpuscle

6.9K
Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

Area of Science:

  • Developmental biology
  • Epigenetics
  • Stem cell biology

Background:

  • Polycomb group (PcG) proteins are crucial epigenetic regulators.
  • PcG proteins orchestrate gene expression hierarchies essential for cellular differentiation.
  • Understanding PcG protein function is key to stem cell biology.

Discussion:

  • Ezhkova et al. demonstrate the role of PcG-mediated repression in epidermal differentiation timing.
  • This study highlights the precise control PcG proteins exert over developmental processes.
  • The findings link epigenetic mechanisms to lineage-specific differentiation pathways.

Key Insights:

  • Polycomb group protein repression dictates the timing of epidermal precursor cell differentiation.
  • This epigenetic control ensures proper progression through differentiation stages.
  • The study provides a molecular basis for understanding developmental timing.

Outlook:

  • Further research can explore specific PcG targets in epidermal development.
  • Investigating PcG roles in other stem cell lineages may reveal conserved mechanisms.
  • Therapeutic strategies targeting PcG proteins could influence regenerative medicine.