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Seizures and cerebritis associated with administration of OKT3

P M Capone1, M E Cohen

  • 1Department of Neurology, State University of New York, Buffalo.

Pediatric Neurology
|July 1, 1991
PubMed

Insights

OKT3 therapy, used for renal transplant rejection, can cause aseptic meningitis. This case report details new findings of cerebritis and seizures associated with OKT3 treatment in a transplant patient.

Area of Science:

  • Nephrology
  • Immunology
  • Neurology

Background:

  • Renal transplantation rejection is a significant clinical challenge.
  • OKT3 therapy, a monoclonal antibody targeting T-cells, is used to prevent rejection.
  • Aseptic meningitis is a known side effect of OKT3 therapy.

Observation:

  • A patient undergoing treatment for renal transplantation rejection was initiated on OKT3 therapy.
  • The patient subsequently developed lateralizing seizures.
  • Magnetic resonance imaging confirmed the presence of cerebritis.

Findings:

  • Cerebritis and lateralizing seizures were observed in a renal transplant patient receiving OKT3 therapy.
  • These neurological findings were directly associated with the initiation of OKT3 treatment.
  • This represents the first documented instance of cerebritis and seizures linked to OKT3 therapy.

Implications:

  • The findings expand the known spectrum of adverse neurological events associated with OKT3 therapy.
  • Clinicians should be vigilant for neurological symptoms, including seizures and cerebritis, in patients receiving OKT3.
  • Further research may be warranted to understand the mechanism of OKT3-induced cerebritis and seizures.

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