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Identification of tumor-associated antigens by using SEREX in hepatocellular carcinoma
Kaijuan Wang1, Xueqin Xu, Yifei Nie
1Department of Epidemiology, Zhengzhou University, China.
Aim:
To identify biomarkers for diagnosis and prognosis of hepatocellular carcinoma (HCC).
Methods:
Screening the HCC cDNA library with HCC patients sera. Isolated proteins were used as antigens to detect antibodies from patients with HCC and control sera.
Results:
Eighty-one positive clones were identified. The frequencies of autoantibody against five HCC-associated antigens were higher in HCC than that in chronic hepatitis and normal human sera. The sensitivity and specificity of KRT23, AHSG and FTL antigens combination tests up to 98.2% in joint test and 90.0% in series test separately.
Conclusions:
HCC associate antigens identified from this study supply candidate markers of diagnosis, combined detection and immunotherapy of HCC.
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