Related Experiment Video
Updated: Jun 24, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Formulation development of oral controlled release tablets of hydralazine: optimization of drug release and
Bhupinder Singh1, Sonia Pahuja, Rishi Kapil
1University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India. bsbhoop@yahoo.com
Abstract:
The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Modified-Release Drug Delivery Systems: Influencing Factors
Oral Drug Delivery Systems: Continuous-Release Systems
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Oral Drug Delivery Systems: Introduction
Modified-Release Drug Delivery Systems: Rate-Programmed II
