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Related Concept Videos

IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the C=O, C=N, and C=C occur between 1600–1850 cm−1.
The...

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A Multimodal Wide-Field Fourier-Transform Raman Microscope
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Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.

G Vizzeri1, R N Weinreb, A O Gonzalez-Garcia

  • 1Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.

The British Journal of Ophthalmology
|March 24, 2009
PubMed
Summary
This summary is machine-generated.

Spectral-domain optical coherence tomography (SD-OCT) shows high reproducibility for retinal nerve fibre layer (RNFL) measurements. However, SD-OCT and time-domain OCT (TD-OCT) measurements are not interchangeable due to systematic differences.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Retinal nerve fibre layer (RNFL) thickness is a key indicator in glaucoma diagnosis.
  • Assessing RNFL thickness requires reliable and reproducible imaging techniques.
  • Comparing different optical coherence tomography (OCT) technologies is crucial for clinical practice.

Purpose of the Study:

  • To evaluate the reproducibility of spectral-domain OCT (SD-OCT) for RNFL measurements.
  • To assess the agreement between SD-OCT and time-domain OCT (TD-OCT) RNFL measurements.

Main Methods:

  • Acquired SD-OCT and TD-OCT scans from healthy participants and glaucoma patients.
  • Evaluated SD-OCT reproducibility using within-subject standard deviation, coefficient of variation, and intraclass correlation coefficient.
  • Assessed agreement between SD-OCT and TD-OCT using correlation and Bland-Altman plots.

Main Results:

  • SD-OCT demonstrated excellent reproducibility for RNFL thickness in both healthy and glaucoma patient groups.
  • Strong correlations were observed between RNFL parameters measured by SD-OCT, especially for average RNFL thickness.
  • Bland-Altman analysis revealed good agreement between SD-OCT and TD-OCT, though TD-OCT yielded thicker RNFL measurements.

Conclusions:

  • SD-OCT is a highly reproducible method for measuring RNFL thickness.
  • While there is good agreement, SD-OCT and TD-OCT measurements are not interchangeable due to systematic differences.
  • Clinicians should be aware of the differences when interpreting RNFL data from different OCT devices.