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Inflammation

Inflammation

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Imaging Studies VII: Vascular Imaging

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

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Related Experiment Video

Updated: Jun 24, 2026

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

Inflammation imaging in atherosclerosis.

James H F Rudd¹, Fabien Hyafil, Zahi A Fayad

¹Division of Cardiovascular Medicine, Cambridge University, UK. jhfr2@cam.ac.uk

Arteriosclerosis, Thrombosis, and Vascular Biology

|March 24, 2009

Summary

This summary is machine-generated.

Noninvasive imaging techniques can measure inflammation in atherosclerotic plaques. This approach aids in developing new atherosclerosis treatments and identifying patients prone to plaque rupture.

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Area of Science:

Cardiovascular imaging
Atherosclerosis research
Inflammation biology

Background:

Inflammation plays a critical role in the development and progression of atherosclerotic plaques.
Understanding plaque inflammation is key to managing cardiovascular disease risk.

Purpose of the Study:

To review noninvasive imaging modalities for quantifying atherosclerotic plaque inflammation.
To discuss the potential applications of these imaging techniques in drug development, risk stratification, and disease biology.

Main Methods:

Discussion of various imaging modalities capable of assessing plaque inflammation.
Focus on noninvasive techniques for in vivo plaque characterization.

Main Results:

Several imaging modalities demonstrate the ability to noninvasively quantify plaque inflammation.
These techniques offer potential for evaluating therapeutic interventions and patient risk.

Conclusions:

Noninvasive imaging of plaque inflammation holds significant promise for advancing atherosclerosis research.
Applications include testing novel antiatherosclerosis drugs, identifying high-risk patients, and deepening biological insights.