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Related Experiment Video

Updated: Jun 24, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPV1: a target for next generation analgesics.

Louis S Premkumar¹, Parul Sikand

¹Department of Pharmacology, Southern Illinois University School of Medicine Springfield, IL 62702, USA. lpremkumar@siumed.edu

Current Neuropharmacology

|March 24, 2009

Summary

Transient Receptor Potential Vanilloid 1 (TRPV1) channels are key to sensing pain and temperature. Understanding TRPV1

Keywords:

TRPV1 inflammatory mediators nociceptive ion channels.nociceptors pain protein kinases

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Last Updated: Jun 24, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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Published on: December 31, 2013

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Background:

Transient Receptor Potential Vanilloid 1 (TRPV1) is a calcium-permeant cation channel found in primary afferent neurons.
TRPV1 plays a crucial role in detecting thermal and chemical stimuli, particularly those associated with inflammatory pain.
Its distribution extends to both peripheral and central nervous system terminals, influencing action potential initiation and neurotransmitter release.

Purpose of the Study:

To discuss the distribution and functions of TRPV1.
To explore the potential of TRPV1 agonists and antagonists as analgesics.
To highlight non-nociceptive functions of TRPV1 that may cause adverse effects.

Main Methods:

Gene deletion studies to reveal TRPV1's role in pain detection.
Analysis of TRPV1 distribution in neuronal terminals and the central nervous system.
Review of current research on TRPV1 antagonists for analgesic development.

Main Results:

TRPV1 deletion significantly impacts the detection of nociceptive and thermal inflammatory pain.
TRPV1's presence in non-thermal sensory pathways suggests roles beyond pain sensing.
TRPV1 is a promising target for novel analgesic therapies.

Conclusions:

TRPV1 is a critical sensor for pain and temperature.
Further research into TRPV1's diverse functions is needed to optimize analgesic strategies.
Understanding non-nociceptive roles is essential for predicting and mitigating potential side effects of TRPV1-targeting drugs.