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Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

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Published on: December 14, 2014

Population admixture modulates risk for alcohol dependence.

Lingjun Zuo¹, Xingguang Luo, Jennifer B Listman

¹Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA. Lingjun.Zuo@yale.edu

|March 24, 2009

Summary

This summary is machine-generated.

Population admixture influences psychiatric disorder risk. In European-Americans, higher admixture correlated with lower risk for substance dependence, particularly alcohol dependence (AD).

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Area of Science:

Population genetics
Psychiatric epidemiology
Genetics of psychiatric disorders

Background:

Population admixture in America has implications for medical disorder risk.
Previous research suggests admixture impacts various health outcomes.
The role of admixture in psychiatric disorders requires further investigation.

Purpose of the Study:

To investigate the role of population admixture in the risk for psychiatric disorders among European-Americans (EAs) and African-Americans (AAs).
To compare admixture levels between healthy controls and individuals with specific psychiatric conditions, including substance dependence (SD), social phobia, affective disorders, and schizophrenia.

Main Methods:

A multisite study involving 3,792 subjects (3,119 EAs, 673 AAs) and 78 West Africans.
Estimation of admixture proportions using ancestry-informative genetic markers and the STRUCTURE program.
Comparison of admixture levels between cases (diagnosed with psychiatric disorders) and healthy controls.

Main Results:

African admixture was higher in AAs than EAs.
In EAs, a significantly lower degree of African admixture was observed in patients with substance dependence (SD), primarily alcohol dependence (AD), compared to controls (P = 0.009 for SD; P = 0.008 for AD).

Conclusions:

Population admixture may modulate the risk for alcohol dependence in European-Americans.
Admixture might offer protection against alcohol dependence, potentially through increased heterozygosity and reduced risk of deleterious recessive alleles.
Potential selection bias due to the multisite nature of the study cannot be excluded.