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Related Experiment Video

Updated: Jun 24, 2026

gP2S, an Information Management System for CryoEM Experiments

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

Sharing data between LSDBs and central repositories.

Johan T den Dunnen¹, Rolf H Sijmons, Paal S Andersen

¹Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands. ddunnen@lumc.nl

|March 24, 2009

Summary

This summary is machine-generated.

Locus-Specific Databases (LSDBs) face requests to share DNA variant data with large repositories. The Human Genome Variation Society (HGVS) developed recommendations for LSDBs on data sharing with central data repositories.

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Area of Science:

Genomics
Bioinformatics
Data Management

Background:

Locus-Specific Databases (LSDBs) curate vital DNA variant data.
Major data repositories like NCBI and UCSC are requesting data sharing from LSDBs.
This has raised significant questions within the scientific community regarding data sharing protocols.

Purpose of the Study:

To summarize discussions within the Human Genome Variation Society (HGVS) concerning data sharing requests.
To establish clear recommendations for LSDBs on how to share DNA variant data with central repositories.
To facilitate consistent and ethical data sharing practices in genomics.

Main Methods:

Community consultation and discussion within the HGVS.
Analysis of issues raised by LSDBs regarding data sharing.
Synthesis of community feedback into actionable recommendations.

Main Results:

Extensive discussions were held within the LSDB and HGVS communities.
A consensus was reached on key considerations for data sharing.
Specific recommendations for LSDBs were formulated.

Conclusions:

LSDBs need clear guidelines for sharing DNA variant data with central repositories.
The HGVS provides a framework for addressing these data sharing challenges.
Recommendations aim to ensure responsible and effective data dissemination in human genomics.