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Related Experiment Video

Updated: Jun 24, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Treatment for Epstein-Barr virus-associated PTLD.

Thomas G Gross1

  • 1Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, Columbus, OH 43205, USA. Thomas.gross@nationwidechildrens.org

Herpes : the Journal of the IHMF
|March 25, 2009
PubMed
Summary
This summary is machine-generated.

Epstein-Barr virus (EBV) drives post-transplant lymphoproliferative disease (PTLD) due to poor T-cell control. Research focuses on better risk prediction, preemptive treatments, and effective therapies for PTLD.

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
06:38

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Published on: November 8, 2011

Area of Science:

  • * Transplantation Immunology
  • * Oncology
  • * Infectious Diseases

Background:

  • * The link between Epstein-Barr virus (EBV) and post-transplant lymphoproliferative disease (PTLD) is well-established in transplant recipients.
  • * PTLD pathogenesis involves inadequate EBV-specific cytotoxic T-cell control over EBV-infected B-cells.
  • * PTLD continues to be a major cause of illness and death in transplant patients.

Purpose of the Study:

  • * To highlight critical research areas for improving PTLD management.
  • * To address the clinical challenge of selecting optimal therapies for PTLD.
  • * To identify strategies for reducing PTLD morbidity and mortality.

Main Methods:

  • * Review of existing knowledge on EBV and PTLD pathogenesis.
  • * Identification of key areas for future clinical investigation and therapeutic development.
  • * Analysis of obstacles hindering progress in PTLD treatment.

Main Results:

  • * Current understanding points to impaired T-cell immunity as the core issue in PTLD.
  • * Several therapeutic avenues require further investigation, including immunosuppression reduction, risk stratification, preemptive strategies, rituximab utility, and novel treatments for refractory disease.
  • * Disease and patient heterogeneity, along with varied treatment approaches, present significant challenges.

Conclusions:

  • * PTLD remains a significant clinical challenge despite understanding its association with EBV.
  • * Further research is essential to refine risk prediction, develop preemptive therapies, and optimize treatment strategies for PTLD.
  • * Enhanced collaboration among specialists and large-scale prospective trials are crucial for advancing PTLD care.