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[Ventricular assist device and heart transplantation in Japan]

Minoru Ono1

  • 1Department of Cardiothoracic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.

Masui. the Japanese Journal of Anesthesiology
|March 25, 2009
PubMed

Insights

Ventricular assist devices (VADs) treat end-stage heart failure, offering options like bridging to transplant or permanent support. Japanese survival rates with the approved Toyobo VAD are improving, with ongoing trials for implantable devices.

Area of Science:

  • Cardiology
  • Medical Devices
  • Surgical Technology

Context:

  • End-stage heart failure management.
  • Ventricular assist devices (VADs) serve as a bridge to transplantation, bridge to recovery, or destination therapy.
  • Current VAD landscape in Japan includes approved paracorporeal devices and investigational implantable VADs.

Purpose:

  • To review the application and outcomes of Ventricular Assist Devices (VADs) in treating end-stage heart failure.
  • To compare survival rates of the approved Toyobo VAD in Japan with global heart transplantation data.
  • To highlight the potential advantages and ongoing development of implantable VADs.

Summary:

  • The paracorporeal Toyobo VAD, approved in Japan, shows improving survival rates (75% at 1 and 3 years, 58% at 5 years).
  • Implantable VADs are under clinical trials in Japan, offering benefits like patient discharge and infection resistance.
  • Japanese heart transplantation survival rates (98% at 1 and 3 years, 94% at 5 years) significantly exceed global averages.

Impact:

  • Provides insights into VAD therapy effectiveness in Japan.
  • Informs patients and clinicians about VAD options and outcomes.
  • Highlights Japan's advanced position in heart transplantation success rates.

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