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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Autoimmune Disorders

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Related Experiment Video

Updated: Jun 24, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

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Reactive arthritis: a review.

Paul S Kim1, Thomas L Klausmeier, Donald P Orr

  • 1Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. kim475@iupui.edu

The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine
|March 25, 2009
PubMed
Summary
This summary is machine-generated.

This review covers adolescent reactive arthritis, detailing its causes, diagnosis, and treatment. Understanding these aspects is key for effectively managing this condition in young patients.

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Last Updated: Jun 24, 2026

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Area of Science:

  • Rheumatology
  • Pediatric Rheumatology
  • Immunology

Background:

  • Reactive arthritis is a form of inflammatory arthritis that affects joints.
  • It is characterized by joint inflammation, often following an infection elsewhere in the body.
  • Adolescent cases present unique diagnostic and management challenges.

Purpose of the Study:

  • To provide a comprehensive review of the current literature on adolescent reactive arthritis.
  • To elucidate the pathophysiology, diagnostic approaches, and treatment guidelines for this condition.
  • To enhance the clinical recognition and management of reactive arthritis in adolescents.

Main Methods:

  • Systematic literature search of major biomedical databases.
  • Inclusion of peer-reviewed articles focusing on adolescent reactive arthritis.
  • Synthesis of information regarding epidemiology, etiology, clinical presentation, diagnosis, and management.

Main Results:

  • Reactive arthritis in adolescents shares similarities with adult forms but may have distinct epidemiological and clinical features.
  • Early and accurate diagnosis relies on a combination of clinical findings, laboratory tests, and imaging.
  • Treatment strategies involve addressing the underlying infection, managing joint inflammation, and preventing long-term complications.

Conclusions:

  • Adolescent reactive arthritis requires a thorough understanding of its multifaceted nature.
  • Adherence to established diagnostic criteria and treatment guidelines is crucial for optimal outcomes.
  • Further research is warranted to fully understand the long-term prognosis and optimize therapeutic interventions in this population.