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Neurotrophins and neuronal migration in the developing rodent brain
1Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1072, USA.
Brain Research Reviews
|March 25, 2009
Summary
Neurotrophins regulate neuronal development and survival. Recent studies reveal their new role in guiding neuronal precursor migration in the developing brain.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- Neurotrophins are crucial for neuronal survival, differentiation, function, and plasticity in both developing and adult rodent brains.
- Emerging research suggests neurotrophins also act as motogenic and chemoattractant factors.
Purpose of the Study:
- To summarize and discuss existing evidence on the role of neurotrophins in neuronal precursor migration.
- To highlight the novel motogenic and chemoattractant functions of neurotrophins.
Main Methods:
- Literature review of studies investigating neurotrophin function in the developing brain.
- Analysis of research focusing on neuronal precursor migration and guidance cues.
Main Results:
- Neurotrophins influence the migration of neuronal precursors in the developing mouse brain.
- Evidence supports neurotrophins acting as chemoattractant and motogenic factors for these migrating cells.
Conclusions:
- Neurotrophins play a significant role in directing neuronal precursor migration during brain development.
- This newly identified function expands our understanding of neurotrophin's multifaceted roles in the nervous system.
