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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronisation therapy in paediatric and congenital heart disease: differential effects in various

J Janousek1, R A Gebauer, H Abdul-Khaliq

  • 1Department of Paediatric Cardiology, University of Leipzig, Heart Centre, Strümpellstrasse 39, 04289 Leipzig, Germany. jan.janousek@medizin.uni-leipzig.de

Heart (British Cardiac Society)
|March 25, 2009
PubMed

Insights

Cardiac resynchronisation therapy (CRT) improves heart function in children with congenital heart disease. However, effectiveness varies based on the specific heart condition, with pacing-induced heart failure being a key indication.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Cardiac Electrophysiology

Background:

  • Cardiac resynchronisation therapy (CRT) use is growing in pediatric populations for various conditions.
  • Published data on CRT outcomes in children remain limited.

Purpose of the Study:

  • To document current practices and outcomes of CRT in pediatric patients with congenital heart disease.
  • To analyze factors influencing CRT response in this population.

Main Methods:

  • A retrospective, multicenter European survey was conducted.
  • Data from 109 pediatric patients with structural congenital heart disease, atrioventricular block, or dilated cardiomyopathy were analyzed.
  • Functional and echocardiographic parameters were assessed post-CRT.

Main Results:

  • CRT led to significant improvements in ventricular size, ejection fraction (EF), and New York Heart Association (NYHA) class.
  • Non-response was associated with primary dilated cardiomyopathy and poor NYHA class.
  • A systemic left ventricle was the strongest predictor of improved EF.

Conclusions:

  • Heart failure from ventricular pacing is a primary indication for CRT in pediatric congenital heart disease.
  • CRT efficacy is highly dependent on the patient's underlying cardiac anatomy and pathophysiology.
Abstract

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