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Updated: Jun 24, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Stress cardiomyopathy - a unique presentation of diabetic ketoacidosis
Sudip Nanda1, Santo Longo, Surya Prakash Bhatt
1Department of Internal Medicine, St. Luke's Hospital, Bethlehem, PA, USA. sudipnanda2000@yahoo.com
Abstract:
We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their metabolic substrate to ketones. The myocyte has a decreased ability to metabolize glucose and free fatty acids in stress CMP. To the best of our knowledge this is the first report of stress CMP complicating DKA. A possible mechanism for the same is hypothesized.
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