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Rhinosinusitis in children and asthma severity

Ruby Pawankar1, Mario E Zernotti

  • 1Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.

Current Opinion in Allergy and Clinical Immunology
|March 25, 2009
PubMed

Insights

Pediatric rhinosinusitis is strongly linked to severe asthma. Treating upper airway inflammation, particularly chronic rhinosinusitis, can improve asthma control and reduce its severity in children.

Area of Science:

  • Pediatric respiratory medicine
  • Immunology

Background:

  • Rhinosinusitis is prevalent in children.
  • Asthma and rhinosinusitis share epidemiological and pathogenic links.
  • A correlation exists between sinusitis and asthma severity.

Purpose of the Study:

  • To investigate the relationship between rhinosinusitis and asthma severity in children.
  • To highlight new findings on the association between upper respiratory illness and severe asthma.

Main Methods:

  • Review of existing epidemiological and pathogenic evidence.
  • Analysis of inflammatory profiles in rhinosinusitis and asthma.

Main Results:

  • Both rhinosinusitis and asthma exhibit similar inflammatory cell profiles, notably eosinophils.
  • Severe childhood asthma is frequently associated with upper respiratory conditions like rhinosinusitis.

Conclusions:

  • Effective treatment of chronic rhinosinusitis, whether medical or surgical, positively impacts concurrent asthma.
  • Intervention for chronic rhinosinusitis can lead to a reduction in asthma severity.
Abstract

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