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Related Experiment Videos

Structure of nortriptyline hydrochloride.

C L Klein1, T A Banks, D Rouselle

  • 1Department of Chemistry, Xavier University of Louisiana, New Orleans 70125.

Acta Crystallographica. Section C, Crystal Structure Communications
|July 15, 1991
PubMed
Summary

This study details the crystal structure of nortriptyline hydrochloride, revealing a butterfly fold and specific hydrogen bonding interactions. These findings contribute to understanding the molecular conformation of this antidepressant.

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Area of Science:

  • Crystallography
  • Structural Chemistry
  • Pharmacology

Background:

  • Nortriptyline is a tricyclic antidepressant.
  • Understanding its molecular structure is crucial for drug design and action.

Purpose of the Study:

  • To determine the crystal structure of nortriptyline hydrochloride.
  • To elucidate the molecular conformation and intermolecular interactions.

Main Methods:

  • Single-crystal X-ray diffraction was employed.
  • The crystal structure was solved and refined using Mo K alpha 1 radiation.

Main Results:

  • Nortriptyline hydrochloride crystallized in the monoclinic P2(1)/c space group.
  • A 'butterfly' fold with a 124.3 degree angle was observed.

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  • The propylamino side chain was extended, with the amino nitrogen forming hydrogen bonds to chloride ions.

    • Conclusions:

    • The crystal structure provides precise details of nortriptyline's molecular geometry.
    • Hydrogen bonding interactions involving chloride ions were identified.
    • This structural data can inform the development of related pharmaceutical compounds.