Related Experiment Video
Updated: Jun 24, 2026

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta
Published on: September 8, 2023
Optimizing the role of imaging in appendicitis
1Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G1X8, Canada. andrea.doria@sickkids.ca
Insights
Computed tomography (CT) offers higher accuracy for diagnosing childhood appendicitis than ultrasound (US). However, an integrated clinical-imaging approach can reduce unnecessary radiation exposure in children with low appendicitis risk.
Area of Science:
- Pediatric Surgery
- Diagnostic Imaging
- Radiation Oncology
Background:
- Acute appendicitis is a common surgical emergency in children.
- Computed tomography (CT) shows higher diagnostic sensitivity for appendicitis than ultrasound (US).
- CT use in children raises concerns about radiation exposure and cancer risk.
Purpose of the Study:
- To evaluate the diagnostic performance and safety of imaging modalities for pediatric appendicitis.
- To explore strategies for optimizing imaging use in children with suspected appendicitis.
- To minimize radiation exposure in pediatric patients while ensuring accurate diagnosis.
Main Methods:
- Review of diagnostic performance data for CT and US in pediatric appendicitis.
- Analysis of radiation risks associated with pediatric CT scans.
- Proposal of an integrated clinical-imaging approach using clinical scores.
Main Results:
- CT has superior sensitivity compared to US for diagnosing appendicitis in children.
- Pediatric CT scans carry a quantifiable lifetime risk of radiation-induced cancer.
- Clinical scores can help identify children at low risk for appendicitis, potentially avoiding imaging.
Conclusions:
- An integrated clinical-imaging strategy can enhance diagnostic accuracy and reduce unnecessary radiation exposure in children.
- Careful patient selection for imaging is crucial to balance diagnostic benefits against radiation risks.
- Further research into risk stratification tools is needed to optimize appendicitis diagnosis in pediatric patients.
Abstract:
Acute appendicitis is the most common acute abdominal condition that requires surgical intervention in childhood. From the diagnostic performance perspective, computed tomography (CT) has a significantly higher sensitivity than does ultrasound (US) for diagnosing appendicitis in children; from the safety perspective, however, one should consider the radiation associated with CT, especially in children. There is strong evidence supporting improved patient outcomes in children with suspected acute appendicitis who undergo CT scanning. Nevertheless, we should keep in mind that for a single abdominal CT study in a 5-year-old child, the lifetime risk of radiation-induced cancer would be 26.1 per 100,000 in female and 20.4 per 100,000 in male patients, based on probabilistic models designed with data from atomic bomb survivors. An integrated clinical-imaging approach, applying clinical scores that are able to predict which children with acute abdominal pain do or do not have a high probability of presenting with appendicitis may improve the effectiveness of the imaging diagnosis of appendicitis at the hospital level. Such an approach could avoid exposure of children who at low risk for appendicitis to unnecessary diagnostic tests and eventually, to radiation.
Related Concept Videos
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis
Ultrasonography
During an ultrasonography procedure, a handheld device called a...
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...