Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new diagnostic test for primary aldosteronism.

P Coruzzi1, L Musiari, A Biggi

  • 1Istituto di Semeiotica Medica, Università di Parma, Italy.

American Journal of Hypertension
|August 1, 1991
PubMed
Summary

Head-out water immersion effectively distinguishes between aldosterone-producing adenoma and idiopathic hyperaldosteronism. This diagnostic method assesses renin-aldosterone responsiveness, aiding in primary aldosteronism diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DW-MRI predictive factors for radiation-induced vaginal stenosis in patients with cervical cancer.

Clinical radiology·2019
Same author

The predictive role of interim PET after the first chemotherapy cycle and sequential evaluation of response to ABVD in Hodgkin's lymphoma patients-the Polish Lymphoma Research Group (PLRG) Observational Study.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease.

Leukemia·2015
Same author

Blood pressure changes after high- and low-salt diets: are intermittent arm measures and beat-by-beat finger measures equivalent?

Journal of human hypertension·2014
Same author

Ethnicity-related variations of left ventricular remodeling in adolescent amateur football players.

Scandinavian journal of medicine & science in sports·2014
Same author

Nuclear medicine imaging in lung cancer.

International journal of oncology·2011

Area of Science:

  • Endocrinology
  • Nephrology

Background:

  • Primary aldosteronism is a condition characterized by excessive aldosterone production.
  • Differentiating between aldosterone-producing adenoma and idiopathic hyperaldosteronism is crucial for appropriate patient management.

Purpose of the Study:

  • To evaluate the efficacy of head-out water immersion as a diagnostic tool for distinguishing between aldosterone-producing adenoma and idiopathic hyperaldosteronism.
  • To assess the impact of water immersion on plasma renin activity and aldosterone levels in patients with these conditions.

Main Methods:

  • Six patients with aldosterone-producing adenoma and six with idiopathic hyperaldosteronism underwent head-out water immersion.
  • Plasma renin activity and aldosterone levels were measured before and during immersion.
  • Serum cortisol levels were also monitored.

Related Experiment Videos

Main Results:

  • In aldosterone-producing adenoma patients, plasma aldosterone did not decrease below 10 ng/dL, and the aldosterone-cortisol ratio increased.
  • In idiopathic hyperaldosteronism patients, plasma renin activity and aldosterone levels significantly decreased, with aldosterone invariably falling below 10 ng/dL.
  • Serum cortisol was significantly suppressed in aldosterone-producing adenoma patients.

Conclusions:

  • Head-out water immersion serves as a reliable suppression test for differentiating between aldosterone-producing adenoma and idiopathic hyperaldosteronism.
  • This method is suitable for assessing renin-aldosterone responsiveness in primary aldosteronism.
  • Water immersion is a valuable tool for diagnosing the subtypes of primary aldosteronism.