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Updated: Jun 24, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
Published on: June 26, 2020
Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair
Peter L Graumann1, Tobias Knust
1Microbiology, Faculty for Biology, University of Freiburg, Schänzle Strasse 1, 79104 Freiburg, Germany. peter.graumann@biologie.uni-freiburg.de
Abstract:
Bacteria and archaea possess several different SMC-like proteins, which perform essential functions in a variety of chromosome dynamics, such as chromosome compaction, segregation, and DNA repair. SMC-like proteins localize to distinct sites within the cells at different time points in the cell cycle, or are recruited to sites of DNA breaks and damage. The bacterial SMC (MukB) complex appears to perform a condensin-like function, while SbcC and RecN act early during DNA repair, but apparently at different sites within the cells. Thus, bacterial SMC-like proteins have dynamic functions in chromosome segregation and maintenance of genetic stability.
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