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Updated: Jun 24, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
t(3;9;22) 3-way chromosome translocation in chronic myeloid leukemia is associated with poor prognosis
Jiahuai Tan1, Shundong Cang, Karen Seiter
1Department of Medicine, Mount Vernon Hospital, Mount Vernon, NY, USA.
Abstract:
Chronic myelogenous leukemia (CML) is genetically characterized by the reciprocal translocation of chromosome 9 and 22. Around 5-8% of CML develop complex variant Ph translocations involving one or more chromosomal regions besides 9 and 22. Chromosome 3 is not frequently involved in complex translocations in CML. We report in this study a case of CML displaying a t(3;9;22) 3-way translocation. A review of the literature appears to indicate that CML patients with this translocation tend to have an aggressive course and poor outcome. Additional 3-way chromosome translocations associated with CML are also reviewed.
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