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Rational biosynthetic engineering for optimization of geldanamycin analogues

Woncheol Kim1, Dongho Lee, Seong Su Hong

  • 1Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

Chembiochem : a European Journal of Chemical Biology
|March 25, 2009
PubMed
Summary

Researchers engineered geldanamycin analogues with improved anticancer properties. Site-directed mutagenesis of the polyketide synthase (PKS) and tailoring genes created novel derivatives, like DHQ3, showing enhanced Hsp90 inhibition and potential for better chemotherapy.

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