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Updated: Jun 24, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

Imatinib is a substrate for various multidrug resistance proteins

K Czyzewski1, J Styczynski

  • 1Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Poland. k.czyzewski@cm.umk.pl

Neoplasma
|March 25, 2009
PubMed
Summary

Imatinib resistance in chronic myeloid leukemia (CML) is a growing concern. This study found that increased expression of P-glycoprotein (PGP), MRP1, and LRP contributes to imatinib resistance in CML K-562 cells.

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