Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

TYRAY-Functionalized Alginate Bioinks for 3D Bioprinting Support Stem Cell Culture and Endothelial Network Formation.

ACS biomaterials science & engineering·2025

Same author

Noninvasive Optoacoustic Imaging of Oxygen Saturation Reveals Hypoxic Hematopoietic Bone Marrow during Systemic Inflammation.

Nano letters·2025

Same author

Orchestrated growth factor release for muscle restoration.

Nature materials·2025

Same author

Traction force and mechanosensitivity mediate species-specific implantation patterns in human and mouse embryos.

Science advances·2025

Same author

The Effect of Mechanical Loading on Sprouting Angiogenesis from Engineered Macro-vessel Model.

Small methods·2025

Same author

A stiff bioink for hybrid bioprinting of vascularized bone tissue with enhanced mechanical properties.

Biomaterials·2025

Same journal

Photobiomodulation Targets Mitochondrial Homeostasis for Diabetic Wound Healing.

Tissue engineering. Part B, Reviews·2026

Same journal

Nanotechnology-Driven Noninvasive and Targeted Therapies for Anaplastic Thyroid Carcinoma.

Tissue engineering. Part B, Reviews·2026

Same journal

From Restoration to Regeneration: A Review of 3D Printing Strategies in Digital Dentistry.

Tissue engineering. Part B, Reviews·2026

Same journal

Molecular Pathogenesis of and Regenerative Strategies for Osteonecrosis of the Femoral Head.

Tissue engineering. Part B, Reviews·2026

Same journal

Regenerative Potential of Platelet-Rich Plasma-Loaded Scaffolds in Endometrial Damage: A Meta-Analysis.

Tissue engineering. Part B, Reviews·2026

Same journal

Enhancing Round Window Membrane Permeability for Inner Ear Drug Delivery: A Systematic Review.

Tissue engineering. Part B, Reviews·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Vascularization--the conduit to viable engineered tissues.

Tamar Kaully¹, Keren Kaufman-Francis, Ayelet Lesman

¹Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.

Tissue Engineering. Part B, Reviews

|March 25, 2009

Summary

This summary is machine-generated.

Developing functional blood vessel networks is key for the long-term survival of engineered tissues. This review explores methods to vascularize tissue constructs for better in vitro and in vivo performance.

More Related Videos

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

Related Experiment Videos

Last Updated: Jun 24, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

Area of Science:

Biomedical Engineering
Tissue Engineering
Regenerative Medicine

Background:

Long-term survival of thick engineered tissue constructs is hindered by poor vascularization.
Effective vascularization is crucial for nutrient/waste transport and construct integration post-implantation.

Purpose of the Study:

To review current approaches for vascularizing engineered tissues.
To highlight recent advancements and synergistic strategies in tissue engineering vascularization.

Main Methods:

Review of literature on four main strategies for engineered tissue vascularization:
1. Growth factor delivery from scaffolds.
2. Co-culturing cells.
3. Microfabrication of channels.
4. Decellularization of natural tissues/vessels.

Main Results:

Each approach presents unique advantages for promoting vascularization.
Combining multiple strategies shows synergistic effects, enhancing construct viability.
Recent studies demonstrate progress across all reviewed methods.

Conclusions:

Advancements in vascularization techniques are critical for the clinical translation of engineered tissues.
Synergistic application of different vascularization strategies holds significant promise.
Further research is needed to optimize and integrate these approaches for robust engineered tissues.