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A comparison of thromboelastogram and template bleeding time in the evaluation of platelet function after aspirin
1Department of Anesthesiology, UCLA School of Medicine 90024-1778.
Study Objective:
To compare template bleeding time (TBT) with thromboelastography (TEG) in human subjects after aspirin ingestion.
Design:
Healthy volunteers were given a single 650 mg dose of aspirin or a dose of 650 mg of aspirin on three successive days. TBT and TEG studies were performed prior to aspirin ingestion and 4, 24, 72, and 168 hours after ingestion.
Setting:
Inpatient operating room support area at the UCLA Center for Health Sciences.
Volunteers:
Residents and nurses who were in good general health, had not taken aspirin for 2 weeks, had normal platelet counts, and had no evidence of bleeding or coagulation disorders.
Intervention:
TBT and TEG studies were performed prior to and after the ingestion of aspirin.
Measurements And Main Results:
TBT studies were significantly prolonged at 4, 24, and 72 hours compared with controls. Maximum bleeding time prolongation occurred 24 hours after aspirin ingestion. Bleeding time returned to control values by the end of 168 hours (1 week). No TEG parameter was significantly changed by aspirin ingestion.
Conclusion:
TEG results may not identify patients who have an increased bleeding time as a result of aspirin ingestion.