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Ioxaglate in paediatric angiocardiography
G D Ogle1, M J Swinburn, R M McCredie
1Prince of Wales Children's Hospital, Sydney, New South Wales, Australia.
Insights
Ioxaglate, a low osmolar contrast agent, demonstrated good tolerance and image quality in pediatric patients undergoing angiocardiography for congenital heart disease. While minor side effects occurred, they were not clinically significant, supporting its use in this population.
Area of Science:
- Cardiology
- Radiology
- Pediatrics
Background:
- Low osmolar contrast media (LOCM) are generally better tolerated than conventional media.
- Ioxaglate is a LOCM used in medical imaging.
Purpose of the Study:
- To evaluate the tolerance and image quality of ioxaglate in pediatric patients.
- To assess the safety and efficacy of ioxaglate for angiocardiography in congenital heart disease.
Main Methods:
- A consecutive series of 50 pediatric patients (mean age 5.47 years) underwent angiocardiography.
- Ioxaglate was administered at a mean dose of 2.93 mL/kg.
- Both cine-angiography and digital subtraction angiography were utilized.
Main Results:
- Ioxaglate was generally well tolerated, with minor adverse events observed.
- Three patients developed fever, and one had eosinophilia.
- Serum creatinine increased by a mean of 10 mumol/L, with significant renal dysfunction in 12 patients (20-30 mumol/L increase), but no significant clinical issues.
- Diagnostic image quality was considered good.
Conclusions:
- Ioxaglate is a safe and effective contrast agent for pediatric angiocardiography in congenital heart disease.
- The observed side effects were transient and not clinically significant.
- Good image quality supports the diagnostic utility of ioxaglate in this patient group.
Abstract:
It is generally agreed that low osmolar contrast media are better tolerated than conventional media. This study examined both tolerance and image quality of ioxaglate in a group of paediatric patients undergoing angiocardiography for congenital heart disease. A consecutive series of 50 patients (mean age 5.47 years; range 4 days-14 years) were examined. The mean dose of ioxaglate administered per patient was 2.93 mL/kg. In general, ioxaglate was well tolerated. Three patients became febrile and another developed eosinophilia. Serum creatinine rose by a mean of 10 mumol/L. Significant renal dysfunction occurred in 12 patients with an increase in creatinine of 20-30 mumol/L. In no patient, however, were these effects a significant clinical problem. Diagnostic image quality was generally considered to be good with both cine-angiography and digital subtraction angiographic techniques.