Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Basic fibroblast growth factor in human melanoma.

U Rodeck¹, D Becker, M Herlyn

¹Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.

Cancer Cells (Cold Spring Harbor, N.Y. : 1989)

|August 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Baseline Descending Aortic Diameter Drives Long-Term Failure of Conservative Management in Uncomplicated Type B Aortic Dissection.

Annals of vascular surgery·2026

Same author

[Update on the assessment of the impact of occupational contact allergies in case of occupational skin disease no. 5101].

Dermatologie (Heidelberg, Germany)·2026

Same author

Addressing Endograft Infection After EVAR.

JACC. Case reports·2025

Same author

Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer.

Thrombosis research·2024

Same author

The Use of Short Dilator Tip in Endovascular Branched Arch Repair: A Case Series.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2024

Same author

Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice.

bioRxiv : the preprint server for biology·2024

Same journal

Epithelial cell plasticity in neoplasia.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

Same journal

Uptake of low-density lipoprotein by malignant cells--possible therapeutic applications.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

Same journal

Some thoughts on the cytolytic mechanism of natural killer lymphocytes.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

Same journal

JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

Same journal

A role for cholinesterases in tumorigenesis?

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

Same journal

The soluble interleukin-2 receptor as a marker for human neoplasia and immune status.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991

See all related articles

Basic fibroblast growth factor (bFGF) drives melanoma cell growth through an autocrine mechanism. Inhibiting bFGF suppresses growth, but its production alone doesn't cause melanoma transformation.

Area of Science:

Oncology
Molecular Biology
Cell Biology

Background:

Basic fibroblast growth factor (bFGF) is implicated in human melanoma cell proliferation.
Melanoma cells produce bFGF, unlike normal melanocytes, which require it for in vitro growth.

Purpose of the Study:

To investigate the role of bFGF in melanoma cell growth.
To determine if bFGF acts in an autocrine manner in melanoma.

Main Methods:

Inhibition of bFGF activity using specific antibodies and antisense sequences.
Retrovirus-mediated transfer of bFGF cDNA into normal murine melanocytes.

Main Results:

Inhibiting bFGF activity significantly suppressed melanoma cell growth in vitro.

Related Experiment Videos

Normal melanocytes engineered to express bFGF became independent of exogenous bFGF for growth.

bFGF expression alone did not immortalize or transform melanocytes, indicating it's insufficient for tumorigenesis.

Conclusions:

bFGF plays a crucial autocrine role in melanoma cell proliferation.
While essential for melanoma growth, bFGF production alone does not confer a transformed phenotype.