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Updated: Jun 24, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
[Effects of platelet and fibrinogen on progressive ovarian cancer]
Chun-Ying Li1, Ming Wu, Jing-Yang Yuan
1Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. lcy2008yaya@126.com
Objective:
To assess the effects of platelet and fibrinogen on progressive ovarian cancer.
Methods:
The platelet counts and fibrinogen levels were measured in 180 initially treated ovarian cancer patients within 2 weeks before and 1 week after operation and 6 months after chemotherapy. The results were compared with those of 40 patients with epithelial ovarian neoplasms.
Results:
The platelet counts and fibrinogen levels were significantly higher in ovarian cancer patients than in patients with epithelial ovarian neoplasms (P < 0.05), significantly higher in late stage than in early stage (P < 0.05), and significantly lower after operation than before operation (P < 0.05). The platelet counts and fibrinogen levels were also significantly lower 6 months after operation in patients who responded well to the therapies than the levels before operation (P < 0.05); however, such difference did not exist between patients who were refractory to the therapies 6 months after treatment and the post-operation levels (P > 0.05).
Conclusions:
Platelet and fibrinogen may be closely correlated with progressive ovarian cancer. Monitoring platelet counts and fibrinogen levels are instrumental for the early diagnosis of cancer and metastasis.
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