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Related Concept Videos

Precipitation Gravimetry01:03

Precipitation Gravimetry

Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Nickel allergy, how deep?

Matteo Anselmino1, Marco Ribezzo, Fulvio Orzan

  • 1Cardiology Unit, Department of Medicine, University of Turin, S. Giovanni Battista "Molinette" Hospital, Corso Bramante 88-90, 10126 Turin, Italy. matt.ans@alice.it

Acta Cardiologica
|March 26, 2009
PubMed
Summary
This summary is machine-generated.

This case study addresses percutaneous closure of atrial septal defects in patients with nickel allergy. It highlights successful device implantation despite nickel-titanium alloy concerns.

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Area of Science:

  • Cardiology
  • Biomaterials Science

Background:

  • Atrial septal defects (ASDs) are common congenital heart conditions requiring intervention.
  • Percutaneous closure is a minimally invasive option for ASDs, utilizing implantable devices.
  • Nickel allergy poses a significant challenge for patients requiring nickel-containing medical devices.

Observation:

  • A 41-year-old woman presented with dyspnea due to a 20-mm ASD and right ventricular enlargement.
  • The patient had a confirmed Nickel (Ni2+) allergy via skin patch testing.
  • The chosen atrial septal occluder device is composed of a nickel-titanium alloy (55% Ni, 45% Ti).

Findings:

  • The study evaluated the feasibility of percutaneous closure in a patient with a known nickel allergy.
  • Literature review was conducted to assess risks and alternatives for nickel-allergic patients undergoing device implantation.
  • The case illustrates a successful percutaneous closure of a significant ASD in a nickel-allergic patient.

Implications:

  • This case suggests that percutaneous closure of ASDs may be feasible even in patients with nickel allergy.
  • Careful patient selection and device material considerations are crucial.
  • Further research is warranted on alternative device materials and management strategies for nickel-allergic patients requiring cardiac device implantation.