Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate irradiation does not affect the serum prostatic acid phosphatase level.

D R Christie1, N A Spry, S Marshall

  • 1Wellington Hospital, New Zealand.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|September 1, 1991
PubMed
Summary

Radical pelvic irradiation did not significantly alter serum prostatic acid phosphatase levels in localized prostate cancer patients. Rises in this marker during treatment suggest other disease progression, not treatment effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the reach of an evidence-based public health intervention to optimise nutrition and movement behaviour at scale: The INFANT Program.

Australian and New Zealand journal of public health·2025
Same author

Grading systems for tracheal intubation using videolaryngoscopy.

BJA education·2025
Same author

From fixing to connecting: parents' experiences supporting adult children with eating disorders.

Journal of eating disorders·2024
Same author

Not your average dental swelling….

British dental journal·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Report of the Post-Mortem Examination of the Body of Charles J. Guiteau.

The Chicago medical journal and examiner·2023

Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Prostate cancer management often involves monitoring serum prostatic acid phosphatase.
  • Radical pelvic irradiation is a treatment modality for localized prostate cancer.
  • The impact of irradiation on serum prostatic acid phosphatase levels requires clarification.

Purpose of the Study:

  • To prospectively assess the effect of radical pelvic irradiation on serum prostatic acid phosphatase levels (SPAPL) in patients with localized prostate carcinoma.
  • To determine if changes in SPAPL during or after treatment are attributable to radiation therapy.

Main Methods:

  • Prospective study of 29 consecutive patients with localized prostate carcinoma.
  • Administration of radical pelvic irradiation with doses ranging from 64.00 to 66.00 Gy.

Related Experiment Videos

  • Serial measurement of SPAPLs before, during, and shortly after treatment.

    • Main Results:

    • No significant individual variations in serum prostatic acid phosphatase levels were observed during or after radical pelvic irradiation.
    • The study found no direct correlation between radiation treatment and SPAPL fluctuations.

    Conclusions:

    • Observed increases in serum prostatic acid phosphatase in prostate cancer patients undergoing pelvic irradiation are unlikely to be treatment-related.
    • Such rises warrant investigation for occult pelvic nodal or bony disease progression.