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Error calculation for the PSA quotient
1Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany. arneth@zentrallabor.klinik.uni-mainz.de
Objective:
Prostate specific antigen (PSA) assays have significant measurement errors, but the error associated with the PSA quotient (free to total PSA) often remains unknown.
Methods:
We used both Gaussian error calculation and measurement of imprecision to investigate the level of error associated with the PSA quotient.
Results:
Surprisingly, we found that the error of the PSA quotient at low levels is markedly smaller than that of the total PSA value.
Conclusions:
The PSA quotient should be calculated and considered as a clinically relevant value.
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