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Related Experiment Video

Updated: Jun 24, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Soluble CD14 in periodontitis.

Elena A Nicu1, Marja L Laine, Servaas A Morré

  • 1Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands. e.nicu@acta.nl

Innate Immunity
|March 26, 2009
PubMed
Summary

Soluble CD14 (sCD14) levels are elevated in periodontitis patients, correlating with disease severity and systemic inflammation markers. These findings highlight sCD14 as a potential indicator in this chronic inflammatory condition.

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Area of Science:

  • Immunology
  • Periodontology
  • Biochemistry

Background:

  • Periodontitis is a chronic infectious disease causing tooth loss, linked to endotoxemia and systemic inflammation.
  • Soluble CD14 (sCD14) plays a role in lipopolysaccharide (LPS) binding and immune response.
  • Factors influencing sCD14 levels in periodontitis require further investigation.

Purpose of the Study:

  • To investigate factors contributing to soluble CD14 (sCD14) level variations in periodontitis patients.
  • To assess the relationship between sCD14 levels and markers of systemic inflammation.
  • To explore correlations between sCD14, specific antibodies, and genetic factors in periodontitis.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure sCD14, C-reactive protein (CRP), and specific IgG antibodies (anti-Aggregatibacter actinomycetemcomitans, anti-Porphyromonas gingivalis).

Related Experiment Videos

Last Updated: Jun 24, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

  • Leukocyte, neutrophil, and lymphocyte counts were determined.
  • CD14(-260) genotype was analyzed using a TaqMan allelic discrimination assay.

    • Main Results:

    • Elevated sCD14 levels were significantly more frequent in periodontitis patients compared to controls (P=0.026).
    • sCD14 levels demonstrated a positive correlation with periodontal disease severity (P=0.008), CRP levels (P=0.043), and leukocyte counts (P=0.011).
    • Multivariate analysis indicated that ethnicity, age, and education predicted sCD14 levels, with periodontal destruction severity being a factor in Caucasian subjects.

    Conclusions:

    • Periodontitis is associated with significantly elevated levels of soluble CD14 (sCD14).
    • sCD14 levels correlate with systemic inflammation markers and disease severity in periodontitis.
    • sCD14 may serve as a relevant biomarker in the context of periodontitis and systemic inflammation.