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A web application to perform linkage disequilibrium and linkage analyses on a computational grid

Jules Hernández-Sánchez1, Jean-Alain Grunchec, Sara Knott

  • 1Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Ashworth Laboratories, Edinburgh, UK. jules.hernandez@ed.ac.uk

Bioinformatics (Oxford, England)
|March 26, 2009
PubMed
Summary

Linkage Disequilibrium and Linkage Analysis (LDLA) software enhances complex trait genetic studies. This approach boosts statistical power and computational speed, accelerating genetic discoveries.

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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...