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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Updated: Jun 24, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

Making clinical research a robust career path.

Anthony R Hayward1

  • 1Division for Clinical Research Resources, NCRR, NIH, Bethesda, MD, USA. haywarda@mail.nih.gov

Academic Medicine : Journal of the Association of American Medical Colleges
|March 26, 2009
PubMed
Summary
This summary is machine-generated.

This commentary highlights the National Institutes of Health's vision for clinical and translational research. It emphasizes the need for coordinated education and career support to advance research and improve health outcomes.

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Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
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Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

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Ole Isacson: Development of New Therapies for Parkinson's Disease
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Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

Area of Science:

  • Medical research
  • Translational science
  • Health professions education

Background:

  • Commentary reviews three articles on the National Institutes of Health (NIH) vision for clinical and translational research.
  • Articles cover NIH's Clinical and Translational Science Award (CTSA) program aims, a Harvard training program's success, and the importance of research exposure for medical students.

Discussion:

  • The commentary supports timely recommendations for advancing research within academic health centers.
  • It underscores the necessity of aligning educational initiatives with NIH's broader mission.
  • The author advocates for a unified strategy to integrate research into healthcare professions.

Key Insights:

  • Successful clinical and translational research requires a clear vision and strategic implementation.
  • Medical student exposure to research is crucial for future scientific endeavors.
  • Robust training programs and secure career paths are essential for retaining researchers.

Outlook:

  • Continued focus on NIH-supported research and education programs is vital.
  • Fostering awareness of research importance among healthcare workers is a priority.
  • Developing sustainable research career structures in academic health centers will drive future discoveries.