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Related Experiment Video

Updated: Jun 24, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

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Published on: February 16, 2016

Left ventricular noncompaction.

Antonios A Pantazis1, Perry M Elliott

  • 1The Heart Hospital, University College London/University College London Hospital, London W1G 8PH, UK.

Current Opinion in Cardiology
|March 26, 2009
PubMed
Summary
This summary is machine-generated.

Isolated left ventricular noncompaction (LVNC) is a heart muscle disorder increasingly diagnosed due to better imaging. Genetic factors, particularly sarcomere protein mutations, are now recognized in its development.

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Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Isolated left ventricular noncompaction (LVNC) is a myocardial disorder characterized by excessive left ventricular trabeculations.
  • LVNC is associated with progressive systolic failure, stroke, and arrhythmia.
  • Improved echocardiographic technology has led to a dramatic increase in LVNC diagnoses.

Purpose of the Study:

  • To review current clinical literature on LVNC.
  • To focus on limitations of current diagnostic criteria for LVNC.
  • To present emerging data on the genetics of LVNC.

Main Methods:

  • Literature review of current clinical studies on LVNC.
  • Analysis of diagnostic criteria and their impact on LVNC frequency.
  • Examination of genetic data related to LVNC.

Main Results:

  • Up to 50% of adult LVNC patients have mutations in cardiac sarcomere genes.
  • LVNC may represent a disease paradigm where cardiomyopathic mutations cause abnormal ventricular morphogenesis.
  • Diagnostic criteria significantly influence the perceived frequency of LVNC.

Conclusions:

  • Current diagnostic criteria for LVNC have limitations.
  • Genetic factors, especially sarcomere protein mutations, play a significant role in LVNC.
  • LVNC is increasingly recognized as a distinct myocardial disorder with a genetic basis.