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Updated: Jun 24, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
Eric Vivier1, Hergen Spits, Tom Cupedo
1Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, INSERM, U631, France.
Abstract:
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed in utero in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORgammat) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.
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