Related Experiment Video

Updated: Jun 24, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke

Robin Lemmens1, Shérine Abboud, Wim Robberecht

  • 1Department of Neurology, University Hospitals Leuven, Leuven, Belgium. robin.lemmens@med.kuleuven.be

European Journal of Human Genetics : EJHG
|March 26, 2009
PubMed

Insights

A specific gene variant on chromosome 9p21 is linked to coronary artery disease (CAD) in Belgians. This variant was not associated with cerebrovascular disease (CVD) alone, suggesting different disease pathways.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Neurology

Background:

  • Genome-wide association studies (GWAS) have identified chromosome 9p21 variants linked to myocardial infarction.
  • Coronary artery disease (CAD) and cerebrovascular disease (CVD) may share common underlying pathological mechanisms.
  • The specific role of 9p21 variants in Belgian populations with CAD and CVD requires further investigation.

Purpose of the Study:

  • To investigate the association between chromosome 9p21 variants and coronary artery disease (CAD) in a Belgian population.
  • To examine the association of 9p21 variants with cerebrovascular disease (CVD), considering potential shared pathways with CAD.
  • To conduct a systematic review and meta-analysis to confirm findings across studies.

Main Methods:

  • Genotyping of SNP rs10757278 on chromosome 9 in 926 CAD patients, 648 CVD patients, and 828 controls from Belgian cohorts.
  • Statistical analysis including odds ratio (OR) calculation to determine the association strength.
  • Systematic review and meta-analysis were performed for both CAD and CVD to consolidate evidence.

Main Results:

  • The risk allele rs10757278(*)G showed a significant association with CAD (OR=1.35, P=1.3 x 10(-5)).
  • No significant association was found between rs10757278 and CVD (OR=1.03, P=0.73).
  • Meta-analysis confirmed a consistent association with CAD, but only a marginal association with CVD that disappeared when excluding CAD patients.

Conclusions:

  • The chromosome 9 risk variant rs10757278 is associated with coronary artery disease in the Belgian population.
  • This specific variant is not associated with isolated cerebrovascular disease, indicating distinct pathogenic mechanisms.
  • Findings highlight the importance of population-specific genetic associations and differential disease etiology.

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.