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Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
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Systolic and diastolic heart function in SLE patients.

Margaret Wislowska1, D Dereń, M Kochmański

  • 1Department of Rheumatology, Central Clinical Hospital, 02-507 Warsaw, Poland. mwislowska@wp.pl

Rheumatology International
|March 26, 2009
PubMed
Summary

Systemic lupus erythematosus (SLE) patients often show impaired left ventricular (LV) diastolic function, especially with longer disease duration or higher SLE Disease Activity Index (SLEDAI). Early detection through echocardiography is crucial for managing cardiovascular risks in SLE.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Echocardiography

Background:

  • Cardiovascular pathology is a frequent complication in patients with systemic lupus erythematosus (SLE).
  • Left ventricular (LV) diastolic dysfunction is a common, often subclinical, finding in SLE patients.
  • Assessing cardiac function is vital for managing SLE patients and preventing cardiovascular events.

Purpose of the Study:

  • To evaluate left ventricular (LV) systolic and diastolic function in SLE patients without clinically apparent heart disease.
  • To determine the correlation between SLE duration, disease severity (SLEDAI), and the degree of LV diastolic dysfunction.
  • To compare echocardiographic parameters between SLE patients and a healthy control group.

Main Methods:

  • Pulsed Doppler echocardiography was used to assess LV systolic and diastolic function.
  • SLE patients and age-matched healthy volunteers were included in the study.
  • Echocardiographic measurements were compared between groups, and correlations with SLE duration and SLEDAI were analyzed.

Main Results:

  • No significant differences in systolic function were observed, except for lower fractional shortening in SLE patients, particularly those with long disease duration (>10 years) or high SLEDAI (>6).
  • SLE patients exhibited impaired diastolic function, evidenced by higher late diastolic velocity (A') and lower E'/A' ratios compared to controls.
  • Longer disease duration and higher SLEDAI were associated with worse LV diastolic properties, including longer isovolumetric relaxation time and lower E/A and E'/A' ratios.

Conclusions:

  • Subclinical left ventricular (LV) diastolic dysfunction is prevalent in SLE patients, particularly those with long-standing or active disease.
  • Echocardiography can detect early signs of cardiac involvement in SLE, aiding in risk stratification and management.
  • Monitoring diastolic function is recommended for SLE patients to mitigate cardiovascular complications.