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Updated: Jun 24, 2026

The Combination of Mechanically Isolated Stromal Vascular Fraction and Fibrin Hydrogel: A Processing Protocol
Published on: November 17, 2023
Control of severe portal bleeding by carrier-bound fibrin sealant
Carlos Apestegui1, Stefan Breitenstein, Philipp Dutkowski
1The Swiss Hepato-Pancreatico-Biliary (HPB) Center, Department of Visceral and Transplant Surgery, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland.
Bleeding during liver surgery and liver transplantation (LT) can be caused by coagulation disorders, portal vein hypertension, and adhesions from previous surgical procedures. We describe here how we controlled life-threatening bleeding from a portal vein anastomosis during a third cadaveric LT, by using a carrier-bound sealant (TachoSil). This technique proved effective to control severe anastomotic portal bleeding in this situation. It represents a helpful option in the field of LT, when vascular bleeding cannot be stopped by other methods.
Bleeding during liver surgery and liver transplantation (LT) can be caused by coagulation disorders, portal vein hypertension, and adhesions from previous surgical procedures. We describe here how we controlled life-threatening bleeding from a portal vein anastomosis during a third cadaveric LT, by using a carrier-bound sealant (TachoSil). This technique proved effective to control severe anastomotic portal bleeding in this situation. It represents a helpful option in the field of LT, when vascular bleeding cannot be stopped by other methods.
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