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Related Experiment Video

Updated: Jun 24, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

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Published on: July 5, 2021

[Diffuse astrocytoma presenting as an optic-spinal syndrome].

I Pareés1, J Alonso, A Rovira

  • 1Unidad de Neuroinmunología Clínica, Hospital Universitari Vall d'Hebron, Barcelona, España. iparees@hotmail.com

Revista De Neurologia
|March 26, 2009
PubMed
Summary

Grade II astrocytomas rarely affect the spinal cord. Misdiagnosis as demyelinating disease is possible, highlighting the need for brain biopsy in definitive diagnosis.

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Area of Science:

  • Neurology
  • Neuro-oncology

Background:

  • Spinal cord involvement is an uncommon manifestation of grade II astrocytomas.
  • Distinguishing these tumors from central nervous system inflammatory demyelinating diseases can be clinically challenging.

Observation:

  • A 32-year-old male presented with subacute spinal cord syndrome, initially treated with corticosteroids with partial improvement.
  • Recurrence with vision loss led to advanced imaging revealing widespread central nervous system lesions.

Findings:

  • Magnetic Resonance Imaging (MRI) with spectroscopy identified an infiltrative lesion consistent with low-grade astrocytoma.
  • Brain biopsy confirmed a diffuse fibrillary astrocytoma diagnosis.

Implications:

  • Corticosteroid responsiveness and oligoclonal bands in cerebrospinal fluid do not exclude neoplastic processes.
  • Definitive diagnosis of central nervous system lesions often necessitates brain biopsy for accurate differentiation between inflammatory and neoplastic conditions.