Related Experiment Video
Updated: Jun 24, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases
Gunnar Pejler1, Magnus Abrink, Sara Wernersson
1Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden. gunnar.pejler@afb.slu.se
Abstract:
Serglycin (SG), like all other proteoglycans, consists of a protein "core" to which sulfated and thereby negatively charged polysaccharide chains of glycosaminoglycan type are attached. The recent generation of mice lacking a functional SG gene has revealed a number of biological functions of SG. In particular, it has been shown that SG has a key role in promoting the storage and in regulating the activities of a number of proteases expressed in hematopoietic cell types, most notably various mast cell proteases. In this review, we summarize the recent development in our understanding of the biological function of SG, in particular by focusing on the novel insight provided through analysis of the SG-deficient mouse strain.
Related Concept Videos
Matrix Proteoglycans and Glycoproteins
Regulation of Hematopoietic Stem Cells
Proteoglycans
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Role of Matrix Metalloproteases in Degradation of ECM
A...
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
