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Hem-1, a potential membrane protein, with expression restricted to blood cells
R Hromas1, S Collins, W Raskind
1Department of Medicine IB-442, Indiana University Medical Center, Indianapolis 46202-5121.
Biochimica Et Biophysica Acta
|October 8, 1991
Abstract:
Overlapping cDNAs 3.8 kb in length containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.