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Updated: Jan 19, 2026
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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
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Calcium sensing receptor and heart diseases
1Department of Pathophysiology, Harbin Medical University, Harbin 150086, China; Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150086, China.
Summary
The extracellular calcium sensing receptor (CaR) plays a key role in heart function and disease. This review highlights CaR
Area of Science:
- Cardiovascular Biology
- Molecular Cardiology
- G-protein Coupled Receptors
Background:
- Calcium ion acts as a crucial first and second messenger.
- Extracellular calcium sensing receptor (CaR) activation initiates intracellular signaling cascades, including inositol phosphate accumulation and calcium release.
- CaR mediates diverse cellular functions across various cell types.
Purpose of the Study:
- To review the structure and function of CaR.
- To emphasize the role of CaR in cardiac tissues.
- To explore CaR's involvement in cardiac physiology and pathophysiology.
Main Methods:
- Literature review of studies on CaR expression and function in cardiac tissue.
- Analysis of CaR's involvement in apoptosis and cardiac hypertrophy pathways.
Main Results:
- CaR is functionally expressed in rat atria and ventricles.
- CaR is implicated in ischemia/reperfusion-induced apoptosis via caspase-3, FasL/Fas, and ER stress pathways.
- CaR mediates AngII-induced cardiac hypertrophy in neonatal rat cardiomyocytes through the calcineurin (CaN) pathway.
Conclusions:
- CaR likely possesses significant physiological and pathophysiological roles in heart disease.
- Understanding CaR's function in cardiac tissue is critical for developing novel therapeutic strategies.
- Further research into CaR signaling pathways in the heart is warranted.
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