Related Experiment Video
Updated: Jun 24, 2026
Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
Published on: August 23, 2018
Serum adipocytokine levels in prostate cancer patients
Elif Damla Arisan1, Serdar Arisan, Gokhan Atis
11st Urology Clinics, Sişli Etfal Research and Training Hospital, Sisli-Istanbul, Turkey.
Introduction:
We estimated the circulating levels of adipocytokines such as adiponectin and leptin in nonobese nondiabetic prostate cancer (PCa) patients and compared the results with controls and benign prostate hyperplasia (BPH) patients.
Material And Methods:
Fifty patients with PCa, 20 patients with BPH and 50 healthy volunteers were entered into the study. Their blood samples were investigated for adipocytokines with the ELISA method.
Results:
Adiponectin levels were determined as 8.9 and 5.5 microg/ml for the same patients. Leptin concentration was 14.78 ng/ml in organ-confined PCa patients, and 15.24 ng/ml in advanced PCa patients. In control patients, adiponectin and leptin levels were 18.4 and 12.98 ng/ml, respectively.
Conclusion:
Serum adipocytokine levels of PCa patients were significantly different from those of controls and BPH patients who were not obese or diabetic. Therefore, further molecular investigation of these adipocytokines will help understand the mechanism.
