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Related Experiment Video

Updated: Jun 24, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

Building complex tissues: high-throughput screening for molecules required in hair engineering.

Lily F Lee1, Cheng-Ming Chuong

  • 1Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

The Journal of Investigative Dermatology
|March 27, 2009
PubMed
Summary

Researchers developed a novel human folliculoid microsphere assay to advance hair reconstitution. This innovative model offers a significant contribution to the field of hair engineering.

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Dermatology

Background:

  • Fully functional hair reconstitution models are challenging due to complex cellular organization and numerous molecular interactions.
  • Previous models have not fully replicated the intricate biological processes of hair growth.

Discussion:

  • Havlickova et al. (2009) introduce a human folliculoid microsphere assay, a novel approach to hair engineering.
  • This assay provides a simplified yet effective system for studying hair follicle development and function.
  • The microsphere format allows for controlled cellular interactions and molecular analysis.

Key Insights:

  • The human folliculoid microsphere assay represents a significant advancement in creating functional hair models.
  • This model facilitates the study of key molecular pathways involved in hair follicle morphogenesis.

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

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Last Updated: Jun 24, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
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Published on: February 28, 2013

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
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Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

  • It offers a scalable platform for hair research and therapeutic development.

    • Outlook:

    • The developed assay holds promise for future research in hair regeneration and treatments for hair loss disorders.
    • Further refinement of the assay could lead to more complex and physiologically relevant hair follicle models.
    • This work paves the way for improved strategies in reconstructive dermatology and personalized medicine.