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Updated: Jun 24, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
The IL-23/Th17 axis in the immunopathogenesis of psoriasis
Antonella Di Cesare1, Paola Di Meglio, Frank O Nestle
1St John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, UK.
Abstract:
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.
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