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Updated: Jun 24, 2026

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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand
Hugo C Ong1, Jonathan F Arambula, Sreenivasa Rao Ramisetty
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
Abstract:
7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.
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