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Updated: Jun 24, 2026
10:50
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates
Katharina Welser1, Jakob Grilj, Eric Vauthey
1School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UKNG7 2RD.
Chemical Communications (Cambridge, England)
|March 27, 2009
Abstract:
Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.
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