Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Air pollution accountability research: Moving from a chain to a web.

Global epidemiology·2023
Same author

How do parents perceive their children's epileptic seizures? Experiences of the first seizure and changes during the course of the epilepsy.

Epilepsy & behavior : E&B·2023
Same author

Early clinical trial unit tumor board: a real-world experience in a national cancer network.

Journal of cancer research and clinical oncology·2023
Same author

The PERCIVAL detector: first user experiments.

Journal of synchrotron radiation·2023
Same author

Erratum: Azimuthal Anisotropy of K_{S}^{0} and Λ+Λ[over ¯] Production at Midrapidity from Au+Au Collisions at sqrt[s]_{NN}=130  GeV [Phys. Rev. Lett. 89, 132301 (2002)].

Physical review letters·2021
Same author

Erratum: Azimuthal Anisotropy at the Relativistic Heavy Ion Collider: The First and Fourth Harmonics [Phys. Rev. Lett. 92, 062301 (2004)].

Physical review letters·2021
Same journal

[Applying the German demand planning guideline to maternity care provision: regional and socioeconomic disparities].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Medical aids for children and adolescents following the legislative change-a status report].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Doping: caught between fraud, health protection, and responsibility].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Aging with intellectual and developmental disabilities or severe multiple disabilities-health, participation, and care in later life].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Sexual self-determination and disability: 10 years of the ReWiKs project-dynamics and findings].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Legal and societal aspects of doping in sport].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

[Clinical trials: methodological requirements and interpretation].

J Windeler1, S Lange

  • 1Medizinischer Dienst des Spitzenverbandes Bund der Krankenkassen, Lützowstrasse 53, 45141, Essen. j.windeler@mds-ev.de

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|March 27, 2009
PubMed
Summary
This summary is machine-generated.

Clinical trials are essential for evaluating medical interventions, including drugs and diagnostic tests. Modern clinical trial methodology has evolved significantly to ensure reliable results.

Related Experiment Videos

Last Updated: Jun 24, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Area of Science:

  • Medical Research
  • Clinical Epidemiology

Background:

  • Clinical trials are fundamental for assessing the efficacy and safety of medical interventions.
  • Their application spans pharmaceuticals, non-drug therapies, preventive strategies, screening methods, and diagnostic tools.

Purpose of the Study:

  • To elucidate the essential principles of modern clinical trial methodology.
  • To provide an overview of the historical development and recent advancements in trial design and execution.

Main Methods:

  • Review of fundamental concepts in clinical trial design.
  • Discussion of methodological advancements over recent decades.
  • Emphasis on the application of trials in various healthcare domains.

Main Results:

  • Clinical trials serve diverse research questions, particularly in quantifying medical intervention benefits.
  • Established methodologies are continuously refined to enhance trial validity and reliability.

Conclusions:

  • Understanding modern clinical trial methodology is crucial for evidence-based medicine.
  • The continuous evolution of trial methods ensures their ongoing relevance in healthcare research.