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Related Experiment Video

Updated: Jun 24, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Computational method for identifying and quantifying shape features of human left ventricular remodeling.

Siamak Ardekani1, Robert G Weiss, Albert C Lardo

  • 1Institute for Computational Medicine, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA. sardekani@jhu.edu

Annals of Biomedical Engineering
|March 27, 2009
PubMed
Summary

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Computational anatomy tools can quantify heart shape changes in heart failure. This study distinguished between ischemic and non-ischemic cardiomyopathy using multi-detector computed tomographic images.

Area of Science:

  • Cardiovascular Imaging
  • Computational Anatomy
  • Medical Image Analysis

Background:

  • Left ventricular remodeling predicts mortality in heart failure.
  • Objective quantification of remodeling-associated shape changes is needed.
  • Computational anatomy offers potential solutions for quantifying shape changes.

Purpose of the Study:

  • To analyze multi-detector computed tomographic (MDCT) images of ventricular shape.
  • To determine if regional structural characteristics and differences between ischemic and non-ischemic cardiomyopathy can be identified.
  • To demonstrate the feasibility of using computational anatomy tools for quantifying heart shape changes in vivo.

Main Methods:

  • Analysis of MDCT images from patients with ejection fractions (EF) < 35%.

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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: Jun 24, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

  • Construction of average ventricular shape models (templates) for end-diastole (ED) and end-systole (ES) using image matching algorithms.
  • Quantification of ventricular shape differences using Principal Component Analysis (PCA) on transformation fields.

    • Main Results:

    • Significant ventricular shape differences were found at both ED (p = 0.03) and ES (p = 0.03).
    • A learned discrimination rule differentiated ischemic cardiomyopathy (ICM) from non-ischemic cardiomyopathy (NICM) patients with high accuracy (p = 0.008).
    • The novel shape analysis method successfully quantified regional shape differences in remodeled myocardium.

    Conclusions:

    • Application of this novel shape analysis method to clinical cardiac images is feasible.
    • The approach can quantify regional shape differences in remodeled human myocardium.
    • This method may aid in identifying and differentiating remodeling processes in ICM and NICM populations.